![]() Alternate approaches to presbyopia correction produce optical artifacts such as halos and glare that reduce quality of life. This solution allows for corrected distance vision and some intermediate vision, while still necessitating glasses for near vision. The only currently approved accommodating intraocular lens solution provides a limited range of vision restoration and has shown inconsistent surgical and optical performance. The most promising approach to address presbyopia is with accommodating intraocular lenses-designed to move or change shape in response to forces in the eye, changing focus in a manner similar to the natural lens. This is a frustrating outcome, especially after paying a significant amount of money for the cataract procedure and intraocular lens. Therefore, even after a successful lens replacement procedure, patients must continue to use glasses and presbyopia is not fully addressed. Current solutions on the market effectively treat cataracts, but do not restore a full range of unaided vision. The overall goal of this NSF SBIR Phase I project was to establish the feasibility of a novel intraocular lens that is able to treat both cataracts and presbyopia with a single device. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation NSF has not approved or endorsed its content. This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Finally, the prototypes will be assessed for injectability, to assure smooth integration with standard cataract surgical procedures. ![]() These prototypes will then be assessed for accommodative ability - first in an established opto-mechanical model eye experiment, then in an established human cadaver eye experiment. Lens prototypes will then be molded in a biocompatible, medical grade silicone. The first goal of this research will be the design and optimization of the lens utilizing a combination of mechanical and optical modeling. Additionally, the proposed device shape mimics the natural lens, which allows for maximum utilization of the minute forces in the eye and prevents posterior capsular opacification. Current devices and those in development do not exhibit the required level of sensitivity and subsequent accommodative amplitude to warrant significant adoption in the industry. Forces in the eye are minimal, so this level of sensitivity is critical to any effective accommodating intraocular lens solution. It has the potential of levels of accommodation that are on par with accommodative abilities in a healthy, natural human lens. The proposed intraocular lens utilizes a highly sensitive refractive system leveraging large differences in refractive indices and has a mechanism of action unlike any currently in the market. ![]() This device will fill a significant unmet need and has the potential of restoring a range of vision unlike any device currently in the market. With the growing and aging population, these numbers are expected to increase at a rapid rate. The cataract surgical and intraocular lens exchange markets are significant, with 25.5 million IOL implants and $3.3 billion in sales in 2016 worldwide. Alongside improved quality of life, vision correction has the added benefit of increased productivity in the workforce. Such a solution would provide a greatly improved quality of life for patients and would inform future scientific developments in human accommodation and cataract formation. Despite these ever-increasing numbers, there currently is no single product available that restores both visual acuity and a complete range of spectacle-free vision following cataract refractive surgery. Cataract, the irreversible clouding of the lens that results in blurred vision, is expected to affect 30.1 million Americans by 2020. Presbyopia, the age dependent loss in the ability of the eye to adjust focus, is expected to affect 1.37 billion people worldwide by 2020. This SBIR Phase I project aims to address two conditions that are very prevalent in the aging population, presbyopia and cataract, with a single intraocular lens. Primary Place of Performance Congressional District: Kevin Harris (Principal Investigator) Sponsored Research Office:.Henry Ahn (703)292-7069 TI Translational Impacts TIP Dir for Tech, Innovation, & Partnerships SBIR Phase I: Presbyopia Correcting Intraocular Lens with a Novel Refractive System for Restoration of a Complete Range of Vision and Spectacle Independence NSF Org:
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